How Vitamin D Affects Every Organ and Tissue — 15 claims checked against research
What the research says about the claims
The video makes 66 checkable claims. This page covers the 15 with the strongest research behind them, in the order they come up.
01Supported by researchVitamin d receptors are present in nearly every cell of the human body.
Vitamin d receptors are present in nearly every cell of the human body.
“now vitamin d receptors are in almost every single cell if not every single cell of your entire body”
Multiple provided sources confirm that vitamin D receptors (VDR) are ubiquitously expressed across a wide variety of human tissues and organs, supporting the claim that they are present in nearly every cell.
Sources
THE EFFECT OF VITAMIN D ON THE MUSCULOSKELETAL SYSTEM OF WOMEN DURING MENOPAUSE
2025 · Research · Ochilova Nusratoy Ismoil qizi, Indiaminova G.N.
Review Article The Role of the Intraplaque Vitamin D System in Atherogenesis
2016 · Review · Federico Carbone, Fabrizio Montecucco
The vitamin D receptor: contemporary genomic approaches reveal new basic and translational insights
2017 · Review · J. Wesley Pike, Mark B. Meyer
Vitamin D and Its Implications in Various Diseases
2017 · Research · Shubhangi Sharma, Shikhaa Mahajan
Vitamin D and cognitive impairment in geriatric practice
2025 · Research · S. V. Topolyanskaya, Kh. Kostoeva
02Supported by researchVitamin d functions as a hormone, not strictly a vitamin.
Vitamin d functions as a hormone, not strictly a vitamin.
“and in reality though vitamin d is not really a vitamin it's a hormone”
The provided evidence consistently describes vitamin D as a steroid hormone that is synthesized endogenously and acts via receptors, distinguishing it from the traditional definition of a vitamin.
Sources
Vitamin D and Its Implications in Various Diseases
2017 · Research · Shubhangi Sharma, Shikhaa Mahajan
Please explain how vitamin D acts in the body.
2025 · Research · Tripdatabase
Vitamin D dosage
2021 · Research · Ondřej Kaminský
Vitamin D, Diet and Musculoskeletal Health
2023 · Research · Deborah Agostini, Sabrina Donati Zeppa
Vitamin D: a steroid hormone with progesterone-like activity.
2018 · Review · Giovanni Monastra, Simona De Grazia
03Supported by researchVitamin d deficiency can lead to sleep disturbances by affecting the circadian rhythm and sleep centers in the brain.
Vitamin d deficiency can lead to sleep disturbances by affecting the circadian rhythm and sleep centers in the brain.
“if you're deficient in vitamin d you're not going to sleep at night vitamin d helps the circadian rhythm it helps the sleep centers in your brain”
The provided evidence indicates that vitamin D receptors are located in brain regions involved in sleep regulation (such as the suprachiasmatic nucleus) and that vitamin D deficiency is associated with sleep disturbances and altered sleep-wake cycles.
Sources
Vitamin D and Sleep Regulation: Is there a Role for Vitamin D?
2020 · Clinical Trial · Fiammetta Romano, Giovanna Muscogiuri
Lower Serum Calcium Levels Associated with Disrupted Sleep and Rest–Activity Rhythm in Shift Workers
2022 · Research · Yi-Seon Jeon, Seungyeong Yu
Proportion of Vitamin D Deficiency in Subjects with Excessive Day Time Sleepiness in a Tertiary Care Psychiatric setting in Thiruvananthapuram
2021 · Clinical Trial · J. Devika, Arun B. Nair
The Effect of Vitamin D Supplementation on Circadian Rhythms and Sleep
2025 · Review · Ryan S. Gray, Mike Ravn
Research advances in children's sleep and vitamin D levels
2025 · Review · Liuyan Zhu, Dan Yao
04Supported by researchVitamin d deficiency can disrupt sleep by affecting the circadian rhythm and sleep centers in the brain, specifically the suprachiasmatic nucleus.
Vitamin d deficiency can disrupt sleep by affecting the circadian rhythm and sleep centers in the brain, specifically the suprachiasmatic nucleus.
“if you're deficient in vitamin d you're not going to sleep at night vitamin d helps the circadian rhythm it helps the sleep centers in your brain and that center is called the super charismatic nucle…”
Multiple studies indicate that vitamin D receptors are expressed in sleep-regulating brain regions, including the suprachiasmatic nucleus, and that deficiency is associated with disrupted sleep and circadian rhythms.
Sources
Vitamin D and Sleep Regulation: Is there a Role for Vitamin D?
2020 · Clinical Trial · Fiammetta Romano, Giovanna Muscogiuri
Research advances in children's sleep and vitamin D levels
2025 · Review · Liuyan Zhu, Dan Yao
Correlation of Vitamin D and Sleep Disorder in Young People 20-40 years
2021 · Review · Desak Ketut Indrasari Utami, Cokorda Istri Dyah Sintarani
0070 Changes In Sleep And Circadian Rhythm In An Animal Model Of Vitamin D Deficiency.
2019 · Lab Study · Jieun Jung, Jiseung Kang
The effect of vitamin D supplement on the score and quality of sleep in 20–50 year-old people with sleep disorders compared with control group
2017 · Research · Mohammad Shahi Majid, Hosseini Seyed Ahmad
05Supported by researchVitamin d deficiency is consistently observed in individuals with alzheimer's, parkinson's, and dementia.
Vitamin d deficiency is consistently observed in individuals with alzheimer's, parkinson's, and dementia.
“in alzheimer's parkinson's dementia there's always a vitamin d deficiency”
Evidence consistently shows an association between vitamin D deficiency and an increased risk or incidence of dementia and Alzheimer's disease, though causality remains a subject of ongoing investigation.
Sources
Do adults with vitamin D deficiency have increased incidence of dementia?
2016 · Systematic Review · Won‐Woo Lee, Deborah E. Miller
Vitamin D Deficiency and the Increased Risk of Developing Dementia and Alzheimerâs Disease
2017 · Review · Morgan Dalcerri, Ángeles García
Vitamin D’s influence on aging brain function: Literature review
2023 · Systematic Review · S Elsayed, Krupa Patel
Vitamin D and Neuroprotection in Elderly Population
2020 · Meta-Analysis · Abhai Kumar, Rameshwar Nath Chaurasia
Impact of vitamin D on neurocognitive function in dementia, depression, schizophrenia and ADHD
2020 · Lab Study · Nithila Mariam Roy
06Supported by researchVitamin d significantly influences mood.
Vitamin d significantly influences mood.
“your mood is greatly influenced by vitamin d”
Multiple studies indicate that vitamin D levels are associated with mood disorders, with evidence suggesting that supplementation can improve mood in deficient individuals, particularly those with anxiety or depression.
Sources
Vitamin D in Mood Disorders: Systematic Review and Meta-Analysis
2025 · Meta-Analysis · tommaso callovini,
Serum Vitamin D Concentrations Are Associated With Depressive Symptoms in Men: The Sixth Korea National Health and Nutrition Examination Survey 2014
2020 · Research · Sang Jin Rhee, Hyunju Lee
Latent profile analysis of vitamin D and its association with depression severity of hospitalized patients with bipolar depression
2024 · Research · Xiabing Zheng, Dhondee Neeraj
Effect of Vitamin D supplement on mood status and inflammation in Vitamin D deficient Type 2 diabetic women with anxiety: A randomized clinical trial
2019 · Clinical Trial · Reza Amani, Siavash Fazelian
Vitamin D Intake Research
2019 · Research · Heidi Lochen, Alexandra Hall
07Supported by researchVitamin d can reduce skin inflammation.
Vitamin d can reduce skin inflammation.
“it can decrease inflammation on your skin”
Multiple studies indicate that vitamin D plays a role in regulating immune responses in the skin and that its supplementation can help manage or reduce inflammation in various dermatological conditions.
Sources
Vitamin D and the skin
2023 · Review · Naglaa N. El Mongy, Rana F. Hilal
Vitamin D in Patients with Inflammatory Skin Diseases
2025 · Research · Liborija Lugović‐Mihić
The Potential Role of Vitamin D Administration in The Skin Aging Process Through The Inflammatory Pathway: A Systematic Review
2023 · Systematic Review · Maria T.F. Kristianti, Hanna Goenawan
[Research progress of vitamin D in inflammatory skin disease].
2023 · Review · Mu Wang, Yan Yan
Future Challenges of Vitamin D Deficiency: The Impact of Systemic Vitamin D Therapy on Serum Levels and Skin Diseases
2025 · Review · Tea Štrbac, Vana Stojić
08Supported by researchVitamin d acts as an immune modulator, helping to buffer an overactive immune system.
Vitamin d acts as an immune modulator, helping to buffer an overactive immune system.
“it's an immune modulator so it helps buffer an over-reactive immune system”
The provided evidence consistently describes vitamin D as an immunomodulator that regulates inflammatory pathways and helps maintain immune system balance.
Sources
Effects of Vitamin D Supplementation on Exacerbation in Patients with Severe COPD
2022 · Research · J Minov, Sasho Stoleski
Vitamin D: Nutrient, Hormone, and Immunomodulator
2018 · Review · Francesca Sassi, Cristina Tamone
AB005. Vitamin D immunomodulatory effect
2018 · Research · Biljana Vuletić, Nedeljko Radlović
Role of Vitamin D in improving immunity
2024 · Research · Richa Paul
Association between levels of vitamin D and inflammatory markers in healthy women
2016 · Research · Fawaz Azizieh, Khulood Alyahya
09Supported by researchIn the absence of vitamin d, bone becomes softer and malformed.
In the absence of vitamin d, bone becomes softer and malformed.
“without vitamin d the bone is softer and it malforms”
Multiple provided papers confirm that vitamin D is essential for bone health and that a severe shortage leads to conditions like rickets in children and osteomalacia in adults, which are characterized by soft and malformed bones.
Sources
Vitamin D for Healthy Bones
2017 · Research · Hoelscher Day, Sharon, Farrell, Vanessa A.
Increasing Vitamin D Deficiency among Adults
2015 · Research · Dr.Rabindran Chandran, Dr D Sharad Gedam
Valuable verities on vitamin D
2016 · Clinical Trial · Tim Jansen, Johannes J. Rasker
Orthopedic Trauma Patients Most Often Low in Vitamin D
2017 · Review · M.D. Gregory M. Weiss
급성세기관지염과 혈청 비타민 D와의 상관관계
2018 · Research · 정영권
10Supported by researchTeeth are significantly influenced by vitamin d and calcium.
Teeth are significantly influenced by vitamin d and calcium.
“the teeth are highly influenced by vitamin d as well as calcium”
Multiple studies confirm that vitamin D is essential for calcium homeostasis, bone metabolism, and the mineralization of teeth, with deficiency linked to issues like hypocalcified dentin and delayed eruption.
Sources
Vitamin D and orthodontics: an insight review
2018 · Review · Khalid A. Almoammar
Vitamin D Deficiency and its Effects on Tooth Structure and pulpal changes
2021 · Research · Lingam Amara Swapna, Rasheed Abdulsalam
Vitamin D and its Influence on Oral Health: A Literature Review
2023 · Review · Indumathi. K. P, Sibyl Siluvai
Vitamin D Target Genes in Dental Health
2022 · Review · Ashwini Tumkur Shivakumar, Sowmya Halasabalu Kalgeri
Effect of Vitamin D Deficiency on Orthodontic Tooth Movement
2025 · Lab Study · Ossama Abbas
11Supported by researchInsufficient vitamin d can impair muscle recovery after exercise and lead to muscle cramps.
Insufficient vitamin d can impair muscle recovery after exercise and lead to muscle cramps.
“if you don't have enough vitamin d your muscles are not going to recover after exercise there you're going to get muscle cramps”
Multiple studies confirm that vitamin D deficiency is associated with muscle pain, cramps, and weakness, and that supplementation can aid in muscle recovery and injury prevention.
Sources
The effect of vitamin D supplementation on serum total 25(OH) levels and biochemical markers of skeletal muscles in runners
2020 · Research · Aleksandra Żebrowska, Ewa Sadowska‐Krępa
Increasing Vitamin D Deficiency among Adults
2015 · Research · Dr.Rabindran Chandran, Dr D Sharad Gedam
THE ROLE OF VITAMIN D IN MUSCLE PERFORMANCE AND INJURY PREVENTION IN ATHLETES
2025 · Research · Kornelia Kaźmierkiewicz, Martyna Chojnacka
Vitamin D and Skeletal Muscle: Current Concepts From Preclinical Studies
2021 · Review · Christian M. Girgis, Tara C. Brennan‐Speranza
Vitamin D and muscle
2018 · Case Report · Jenny E. Gunton, Christian M. Girgis
12Supported by researchVitamin d is necessary for alleviating muscle aches, cramps, and weakness.
Vitamin d is necessary for alleviating muscle aches, cramps, and weakness.
“so to get rid of achy muscles or cramping muscles or weak muscles you need vitamin d”
Clinical literature identifies muscle weakness, pain, and cramps as symptoms of vitamin D deficiency and supports the use of vitamin D repletion to address these issues.
Sources
Vitamin D deficiency in the critically ill
2016 · Research · W.A.C. Koekkoek, Arthur R. H. van Zanten
Vitamin D and Skeletal Muscle: Current Concepts From Preclinical Studies
2021 · Review · Christian M. Girgis, Tara C. Brennan‐Speranza
More than healthy bones: a review of vitamin D in muscle health
2015 · Review · S. Bobo Tanner, Susan A. Harwell
Vitamin D and muscle
2018 · Case Report · Jenny E. Gunton, Christian M. Girgis
Effect of Vitamin D Supplement Consumption on Muscle Strength, Muscle Function and Body Composition in Vitamin D-deficient Middle-aged Women: A Randomized Clinical Trial
2016 · Clinical Trial · Behnaz Abiri, Mohammadreza Vafa
13Supported by researchThere is a strong association between coronary heart disease and low vitamin d levels.
There is a strong association between coronary heart disease and low vitamin d levels.
“a huge association between coronary heart disease and low vitamin d”
Multiple studies consistently report an association between low vitamin D levels and an increased risk or severity of coronary heart disease and related cardiovascular conditions.
Sources
Association of low levels of vitamin D with chronic stable angina: A prospective case-control study
2016 · Research · Ab. Hameed Raina, MohammadSultan Allai
Vitamin D Status in Patients with Atrial Fibrillation and Heart Failure - Is there a Link?
2021 · Research · Miglena Nikolova, Neshe Nazifova-Tasinova
Original Article Effect of Serum Vitamin D Levels on Cardiovascular Mortality and Cardiovascular Disease Risk
2016 · Clinical Trial · Aaron S. Bennion, Karlen E. Luthy
Association of vitamin D deficiency and premature coronary artery disease.
2019 · Research · Hamid Reza Norouzi, Naghmeh Ziaie
Vitamin D deficiency plays an important role in cardiac disease and affects patient outcome: Still a myth or a fact that needs exploration?
2015 · Review · Zaher Fanari, Sumaya Hammami
14Supported by researchLow vitamin d is highly associated with fatty liver disease and liver inflammation, such as hepatitis.
Low vitamin d is highly associated with fatty liver disease and liver inflammation, such as hepatitis.
“there's a high association with low vitamin d when you have a fatty liver and there's definitely a high association if you have a if you have inflammation in your liver as in hepatitis with low vitam…”
Multiple studies and reviews consistently report that low vitamin D levels are frequently observed in patients with various chronic liver diseases, including hepatitis and non-alcoholic steatohepatitis, and are associated with increased disease severity.
Sources
Influence of vitamin D on liver fibrosis in chronic hepatitis C: A systematic review and meta-analysis of the pooled clinical trials data
2017 · Meta-Analysis · Alia S. Dadabhai, Behnam Saberi
Hepatic Decompensation in Patients with Chronic Liver Disease: Exploring the Role of Vitamin D Deficiency as a Prognostic Marker
2024 · Research · Gauri Nilajkar, Rukma Jagannath Kolwalkar
Interrelationship between Non-Alcoholic Steatohepatitis and Vitamin D: A Mini Review
2024 · Clinical Trial · Anil Kaintura, Mohamed Abdelrahman El Hussein
Beyond bones: Revisiting the role of vitamin D in chronic liver disease
2025 · Clinical Trial · Rodrigo Guerrero-Guerrero, Osvely Méndez-Guerrero
Six-month vitamin D replacement reduces hepatic steatosis in the absence of weight loss
2015 · Meta-Analysis · Ifigeneia Papapostoli, Frank Lammert
15Supported by researchVitamin d deficiency can lead to osteomalacia (softening and malformation of bones), osteopenia (pre-osteoporosis), and osteoporosis (thinning and loss of bone density).
Vitamin d deficiency can lead to osteomalacia (softening and malformation of bones), osteopenia (pre-osteoporosis), and osteoporosis (thinning and loss of bone density).
“if you're deficient in vitamin d you can have osteomalacia which is softening of the bone that's where the bones can start to malform especially early on in life then osteopenia which is kind of like…”
The provided evidence consistently states that vitamin D deficiency leads to abnormalities in bone metabolism, including osteomalacia, osteopenia, and osteoporosis, due to its role in calcium absorption and bone health.
Sources
Prevalence of Vitamin D Deficiency in Nonspecific Musculoskeletal Pain
2015 · Research · Alireza Jalili, Mehrdad Bahrabadi
CYP24A1 Polymorphism Effect on Chronic Drugs Administration and Development of Osteomalacia: A Review Article
2021 · Review · Alyaa Hussein Hammadi, Shatha Hussein Ali
Vitamin D for Healthy Bones
2017 · Research · Hoelscher Day, Sharon, Farrell, Vanessa A.
Increasing Vitamin D Deficiency among Adults
2015 · Research · Dr.Rabindran Chandran, Dr D Sharad Gedam
Assessment of the prevalence and associated factors of vitamin D deficiency among patients age greater than or equal to 18 years presented with musculoskeletal pain in selected public hospitals under Addis Ababa city administration health Bureau, Addis Ababa, Ethiopia
2025 · Research · Nigussie, Libsework, Umer Ali, Abduletif
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